EAR - Ototoxicity

What is ototoxicity?

The tendency of certain therapeutic agents to cause functional impairment and cellular degeneration of the end-organs and neurons of the cochlear and vestibular division of the VIIIth cranial nerve is called ototoxicity. These drugs are called ototoxic drugs.

What are the types of ototoxicity?

Depending on the type of inner ear damage, ototoxicity is divided into:

1) Cochleotoxicity: There is damage to the outer and inner hair cells of the cochlea
2) Vestibutotoxicity: Damage to type I and type II sensory hair cells

What are the common ototoxic drugs?

Some of the common ototoxic drugs are as follows:

A) Aminoglycosides:

B) Diuretics:
Ethacrynic acid

C) Antimalarials:

D) Cytotoxic drugs:
Nitrogen Mustard

D) Analgesics:

E) Miscellaneous:

What are the clinical features of ototoxicity?

The clinical features of ototoxicity are as follows:

1) Tinnitus: Tinnitus usually due to toxic damage to the cochlea. It is high frequency and continuous
2) Hearing loss: Initially there is high frequency sensorineural type of hearing loss. It may however progress to involve the speech frequencies. Aminoglycosides commonly cause this type of hearing loss
3) Disequilibrium: When the vestibular organs are damaged, there is inability to focus sharply and distant objects appear to jump on head movements

How is ototoxicity managed?

Management of ototoxicity:

1) Cessation of the treatment by the ototoxic drug
2) Re-assurance for the tinnitus
3) Sound amplification in the form of hearing aid
4) Tinnitus maskers

Bombay Hospital and Medical Research Center
201, 2nd Floor, New Wing 12,
New Marine Lines
Mumbai - 400020
Contact Phone No: 91-022-25283707 Contact Mob No: 07715050774

Juvekars Nursing Home
17/18, Shivsagar CHS
Opposite Akbarallys,
Off Sion Trombay Road
Chembur East, Mumbai -71
Tel: +91-22-25271140

For any suggestions. Please mail at: feedback@specialist-ent.com

Topic on Noise Pollutions By Dr.Meenesh Juvekar ON AIR 93.5 Red FM With RJ Malishka

Topic on Coughing By Dr.Meenesh Juvekar ON AIR FM GOLD

Topic on Snoring Problems By Dr.Meenesh Juvekar ON AIR FM GOLD